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It is not known whether ondansetron is present in human milkThere are no data on the effects of ZOFRAN on the breastfed infant or the effects on milk productionHoweverit has been demonstrated that ondansetron is present in the milk of rats.

Ondansetron is extensively metabolized in humanswith approximately 5of a radiolabeled dose recovered as the parent compound from the urineThe metabolites are observed in the urineThe primary metabolic pathway is hydroxylation on the indole ring followed by subsequent glucuronide or sulfate conjugation.

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